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A novel encystation specific protein kinase regulates chitin synthesis in Entamoeba invadens

Samanta, Sintu Kumar and Varghese, Sneha Susan and Krishnan, Deepak and Baidya, Mithu and Nayak, Digant and Mukherjee, Sumanta and Ghosh, Sudip K (2018) A novel encystation specific protein kinase regulates chitin synthesis in Entamoeba invadens. In: MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 220 . pp. 19-27.

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Official URL: http://dx.doi.org/10.1016/j.molbiopara.2018.01.003


Phosphorylation is an important post-translational modification of proteins and is involved in the regulation of a variety of cellular events. The proteome of Entamoeba invadens, the reptilian counterpart of Entamoeba histolytica consists of an overwhelming number of putative protein kinases, and some may have a role to play in Entamoeba encystation. In this study, we have identified a novel protein kinase named as EiCSpk (Entamoeba invadens cyst specific protein kinase) which expressed almost exclusively during encystation. It is an active Protein kinase C with a characteristic substrate phosphorylation and auto-phosphorylation property. Gene silencing study has unveiled its role as a regulator of chitin synthesis through transcriptional activation of the chitin synthesis pathway genes along with glycogen phosphorylases that are involved in the influx of glucose from glycogen breakdown for chitin synthesis.

Item Type: Journal Article
Additional Information: Copy right for the article belong to ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
Department/Centre: Division of Biological Sciences > Biochemistry
Depositing User: Id for Latest eprints
Date Deposited: 12 Apr 2018 18:49
Last Modified: 12 Apr 2018 18:49
URI: http://eprints.iisc.ac.in/id/eprint/59528

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