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A Catalytic Enantioselective lodocyclization Route to Dihydrooxazines

Suresh, Rahul and Simlandy, Amit Kumar and Mukherjee, Santanu (2018) A Catalytic Enantioselective lodocyclization Route to Dihydrooxazines. In: ORGANIC LETTERS, 20 (5). pp. 1300-1303.

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Official URL: http://dx.doi.org/10.1021/acs.orglett.8b00002


The first catalytic enantioselective synthesis of 5,6-dihydro-4H-1,2-oxazines bearing an oxygen-containing quaternary stereogenic center has been developed through iodoetherification of gamma,delta-unsaturated oximes. This operationally straightforward reaction is catalyzed by Cinchona alkaloids-based bifunctional tertiary aminothiourea derivatives and furnishes the products generally in good to excellent yields and with moderate to high enantioselectivities (up to 97:3 er).

Item Type: Journal Article
Additional Information: Copy right for the article belong to AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Depositing User: Id for Latest eprints
Date Deposited: 02 Apr 2018 19:57
Last Modified: 02 Apr 2018 19:57
URI: http://eprints.iisc.ac.in/id/eprint/59451

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