Ru(II)-Catalyzed C-H Amidation of Indoline at the C7-Position Using Dioxazolone as an Amidating Agent: Synthesis of 7-Amino Indoline Scaffold

Hande, Akshay Ekanath and Prabhu, Kandikere Ramaiah (2017) Ru(II)-Catalyzed C-H Amidation of Indoline at the C7-Position Using Dioxazolone as an Amidating Agent: Synthesis of 7-Amino Indoline Scaffold. In: JOURNAL OF ORGANIC CHEMISTRY, 82 (24). pp. 13405-13413.

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Abstract

The Ru(II)-catalyzed C-H amidation of indoline at the C7-position en route for synthesizing the 7-amino indole scaffold has been achieved by using dioxazolone, which is an environmentally benign amidating reagent. This protocol paves the way for synthesizing a variety of 7-amino indole derivatives in excellent yields at ambient reaction conditions. The readily cleavable amide group has been utilized as a directing group for the amidation. The derivatives of 7-amino indole are synthetically useful for accessing a variety of natural products, drug molecules, and biologically active compounds.

Item Type:	Journal Article
Publication:	JOURNAL OF ORGANIC CHEMISTRY
Publisher:	10.1021/acs.joc.7b02500
Additional Information:	Copy right for this article belongs to the AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	20 Jan 2018 06:21
Last Modified:	20 Jan 2018 06:21
URI:	http://eprints.iisc.ac.in/id/eprint/58827

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