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Zn(II), Cd(II) and Hg(II) metal complexes of 2-aminonicotinaldehyde: Synthesis, crystal structure, biological evaluation and molecular docking study

Mallela, Ramachary and Konakanchi, Ramaiah and Guda, Ramu and Munirathinam, Nethaji and Gandamalla, Durgaiah and Yellu, Narsimha Reddy and Kotha, Laxma Reddy (2018) Zn(II), Cd(II) and Hg(II) metal complexes of 2-aminonicotinaldehyde: Synthesis, crystal structure, biological evaluation and molecular docking study. In: INORGANICA CHIMICA ACTA, 469 . pp. 66-75.

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Official URL: http://dx.doi.org/10.1016/j.ica.2017.08.042

Abstract

In this report, the ligand, 2-aminonicotinaldehyde (ANA) and its metal complexes Zn(ANA)(2)Cl-2], Cd (ANA)(2)Cl-2] and Hg(ANA)(2)Cl-2] have been synthesized and characterized by analytical and various spectroscopic (IR, Electronic, H-1 and C-13 NMR) studies. The single crystal X-ray diffraction studies of ANA and Zn(ANA)(2)Cl-2] complex have been discussed. It was found that intra/intermolecular hydrogen bonding exists in both compounds and N-atom of pyridine ring of ANA coordinated to the metal ion in tetrahedral fashion. Metal chlorides, ANA and its complexes were subjected to biological screening, antioxidant, in vitro cytotoxicity and EGFR (Epidermal growth factor receptor) targeting molecular docking studies which indicated the synergistic effect of metal complexes on the biological activity than the free ligand and metal chlorides. (C) 2017 Elsevier B.V. All rights reserved.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the ELSEVIER SCIENCE SA, PO BOX 564, 1001 LAUSANNE, SWITZERLAND
Department/Centre: Division of Chemical Sciences > Inorganic & Physical Chemistry
Depositing User: Id for Latest eprints
Date Deposited: 23 Dec 2017 06:13
Last Modified: 23 Dec 2017 06:13
URI: http://eprints.iisc.ac.in/id/eprint/58500

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