Vitamin-B6 Schiff base dioxovanadium(V) complex for targeted visible light-induced anticancer activity

Kumar, Arun and Banerjee, Samya and Mukherjee, Sanjoy and Chakravarty, Akhil R (2017) Vitamin-B6 Schiff base dioxovanadium(V) complex for targeted visible light-induced anticancer activity. In: INDIAN JOURNAL OF CHEMISTRY SECTION A-INORGANIC BIO-INORGANIC PHYSICAL THEORETICAL & ANALYTICAL CHEMISTRY, 56 (8). pp. 805-813.

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Abstract

A dioxovanadium(V) complex of vitamin-B6 Schiff base VO2L] (1) (where H2L center dot HCl is 3-hydroxy-5-(hydroxymethyl)-4-(2-hydroxyphenypimino)methyl)-2-methylpyri din-l-ium chloride) has been prepared and structurally characterized. Its photo-induced cytotoxicity and mechanism of cell death has been studied. Single crystal X-ray structure shows five-coordinate square-pyramidal geometry of the complex having the dianionic O,N,O-donor tridentate vitamin-B6 Schiff base and two cis-oriented oxo ligands bound to V(V). DFT study shows the HOMO located on the amino-phenolic moiety, while the LUMO is on the protonated aromatic unit, i.e., the pyridiniumphenolate moiety. Vitamin-B6 transporting membrane carrier (VTC) pathway seems to be responsible for the higher cellular uptake and activity of the complex into the cervical HeLa and breast cancer MCF-7 cells in preference to the normal embryonic fibroblast 3T3 cells. The complex exhibits reactive oxygen species (ROS) mediated apoptotic photocytotoxicity in visible light of 400-700 nm in the cancer cells (IC50: similar to 16 mu M), while being essentially non-toxic in the dark. Alkaline Comet assay shows damage of the nuclear DNA.

Item Type:	Journal Article
Publication:	INDIAN JOURNAL OF CHEMISTRY SECTION A-INORGANIC BIO-INORGANIC PHYSICAL THEORETICAL & ANALYTICAL CHEMISTRY
Additional Information:	Copy right for this article belongs to the NATL INST SCIENCE COMMUNICATION-NISCAIR, DR K S KRISHNAN MARG, PUSA CAMPUS, NEW DELHI 110 012, INDIA
Department/Centre:	Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	23 Sep 2017 05:03
Last Modified:	03 Oct 2018 15:01
URI:	http://eprints.iisc.ac.in/id/eprint/57877

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