ePrints@IIScePrints@IISc Home | About | Browse | Latest Additions | Advanced Search | Contact | Help

Two zinc finger proteins from Mycobacterium smegmatis: DNA binding and activation of transcription

Ghosh, Subho and Chatterji, Dipankar (2017) Two zinc finger proteins from Mycobacterium smegmatis: DNA binding and activation of transcription. In: GENES TO CELLS, 22 (8). pp. 699-714.

[img] PDF
Gen_Cel_22-8_699_2017.pdf - Published Version
Restricted to Registered users only

Download (1MB) | Request a copy
Official URL: http://doi.org/10.1111/gtc.12507

Abstract

Single zinc finger domain containing proteins are very few in number. Of numerous zinc finger proteins in eukaryotes, only three of them like GAGA, Superman and DNA binding by one finger (Dof) have single zinc finger domain. Although few zinc finger proteins have been described in eubacteria, no protein with single C4 zinc finger has been described in details in anyone of them. In this article, we are describing two novel C-terminal C4 zinc finger proteins-Msmeg_0118 and Msmeg_3613 from Mycobacterium smegmatis. We have named these proteins as Mszfp1 (Mycobacterial Single Zinc Finger Protein 1) and Mszfp2 (Mycobacterial Single Zinc Finger Protein 2). Both the proteins are expressed constitutively, can bind to DNA and regulate transcription. It appears that Mszfp1 and Mszfp2 may activate transcription by interacting with RNA polymerase.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Depositing User: Id for Latest eprints
Date Deposited: 23 Sep 2017 05:05
Last Modified: 23 Sep 2017 05:05
URI: http://eprints.iisc.ac.in/id/eprint/57873

Actions (login required)

View Item View Item