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Super-Resolved Nuclear Magnetic Resonance Spectroscopy

Mulleti, Satish and Singh, Amrinder and Brahmkhatri, Varsha P and Chandra, Kousik and Raza, Tahseen and Mukherjee, Sulakshana P and Seelamantula, Chandra Sekhar and Atreya, Hanudatta S (2017) Super-Resolved Nuclear Magnetic Resonance Spectroscopy. In: SCIENTIFIC REPORTS, 7 .

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Official URL: http://doi.org/10.1038/s41598-017-09884-w

Abstract

We present a novel method that breaks the resolution barrier in nuclear magnetic resonance (NMR) spectroscopy, allowing one to accurately estimate the chemical shift values of highly overlapping or broadened peaks. This problem is routinely encountered in NMR when peaks have large linewidths due to rapidly decaying signals, hindering its application. We address this problem based on the notion of finite-rate-of-innovation (FRI) sampling, which is based on the premise that signals such as the NMR signal, can be accurately reconstructed using fewer measurements than that required by existing approaches. The FRI approach leads to super-resolution, beyond the limits of contemporary NMR techniques. Using this method, we could measure for the first time small changes in chemical shifts during the formation of a Gold nanorod-protein complex, facilitating the quantification of the strength of such interactions. The method thus opens up new possibilities for the application and acceleration of multidimensional NMR spectroscopy across a wide range of systems.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
Department/Centre: Division of Electrical Sciences > Electrical Engineering
Depositing User: Id for Latest eprints
Date Deposited: 23 Sep 2017 05:06
Last Modified: 23 Sep 2017 05:06
URI: http://eprints.iisc.ac.in/id/eprint/57866

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