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New pH-responsive gemini lipid derived co-liposomes for efficacious doxorubicin delivery to drug resistant cancer cells

Moitra, Parikshit and Kumar, Krishan and Sarkar, Sourav and Kondaiah, Paturu and Duan, Wei and Bhattacharya, Santanu (2017) New pH-responsive gemini lipid derived co-liposomes for efficacious doxorubicin delivery to drug resistant cancer cells. In: CHEMICAL COMMUNICATIONS, 53 (58). pp. 8184-8187.

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Official URL: http://doi.org/10.1039/c7cc03320f

Abstract

A gemini version of the amphiphile palmitoyl homocysteine was synthesized. Co-liposomes were prepared using the gemini along with a natural zwitterionic lipid, DOPE and cholesterol at specified ratios. This afforded pH-responsive co-liposomes which could efficiently transport the anticancer drug, doxorubicin (DOX), across the DOX-resistant HeLa cancer cells in response to low pH of cellular endosomes.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Division of Chemical Sciences > Organic Chemistry
Depositing User: Id for Latest eprints
Date Deposited: 12 Aug 2017 04:27
Last Modified: 12 Aug 2017 04:27
URI: http://eprints.iisc.ac.in/id/eprint/57602

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