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Structure and spectroscopic investigations of a bi-dentate N `-(4-ethylphenyl)methylidene]-4-hydroxybenzohydrazide and its Co(II), Ni(II), Cu(II) and Cd(II) complexes: Insights relevant to biological properties

Reddy, N B Gopal and Krishna, P Murali and Kumar, S S Shantha and Patil, P Yogesh and Nethaji, Munirathinam (2017) Structure and spectroscopic investigations of a bi-dentate N `-(4-ethylphenyl)methylidene]-4-hydroxybenzohydrazide and its Co(II), Ni(II), Cu(II) and Cd(II) complexes: Insights relevant to biological properties. In: JOURNAL OF MOLECULAR STRUCTURE, 1137 . pp. 543-552.

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Official URL: http://dx.doi.org/10.1016/j.molstruc.2017.02.009

Abstract

The present paper describes the synthesis of novel ligand, N'-(4-ethylphenyl)methylidene]-4-hydroxy benzohydrazide (HL) and its Co(II), Ni(II), Cu(II) and Cd(II) complexes. The ligand (HL) crystallizes in orthorhombic lattice in P2(1)2(1)2(1) space group with a = 7.9941 (7) angstrom, b = 11.6154 (10) angstrom, c = 15.2278 (13) angstrom, alpha = beta = gamma = 90 degrees. Spectroscopic data gives the strong evidence that ligand is coordinated through azomethine nitrogen and enolic oxygen with metal ion. The DNA binding studies revealed that the complexes bind to CT-DNA via intercalation/electrostatic interaction. All the targeted compounds showed more pronounced DNA cleavage activity in the presence of H2O2 and also inhibit the growth of in vitro antibacterial activity against Gram-positive and Gram-negative bacteria. (C) 2017 Elsevier B.V. All rights reserved.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
Department/Centre: Division of Chemical Sciences > Inorganic & Physical Chemistry
Depositing User: Id for Latest eprints
Date Deposited: 20 May 2017 05:21
Last Modified: 20 May 2017 05:21
URI: http://eprints.iisc.ac.in/id/eprint/56892

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