Zn1-xGdxS (x=0.1, 0.2 and 0.3) nanoparticles for magnetic resonance imaging and optical fluorescence imaging

Venkatesha, N and Poojar, Pavan and Qurishi, Yasrib and Geethanath, Sairam and Srivastava, Chandan (2017) Zn1-xGdxS (x=0.1, 0.2 and 0.3) nanoparticles for magnetic resonance imaging and optical fluorescence imaging. In: MATERIALS RESEARCH EXPRESS, 4 (3).

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Abstract

This work proposes chemically synthesized Gd doped ZnS nanoparticles based system for potential use as contrast enhancing agent for both optical fluorescence imaging and magnetic resonance imaging. Two different Gd doped ZnS nanoparticle systems were synthesized. These systems were (i) graphene oxide-Zn1-xGdxS (x = 0.1, 0.2 and 0.3) nanoparticle composites and (ii) chitosan coated Zn1-xGdxS (x = 0.1, 0.2 and 0.3) nanoparticles. Gd formed solid solution with ZnS in all the six as-synthesized samples. Gd doped ZnS nanoparticles in both cases exhibited both longitudinal and transverse relaxivity values. A clear dependence the relaxivity values on the composition of the nanoparticles and the nanoparticle environment (presence and absence of graphene oxide) was observed. Between the two cases, values of the longitudinal and transverse relaxivity were higher for the graphene oxide-Zn1-xGdxS composites. It is also shown that Gd doped ZnS nanoparticle can be used for fluorescence imaging also. Gd doped ZnS nanoparticle exhibited biocompatibility towards the MCF-7 cell line.

Item Type:	Journal Article
Publication:	MATERIALS RESEARCH EXPRESS
Publisher:	IOP PUBLISHING LTD, TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
Additional Information:	Copy right for this article belongs to the IOP PUBLISHING LTD, TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
Department/Centre:	Division of Biological Sciences > Molecular Reproduction, Development & Genetics Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited:	20 May 2017 05:05
Last Modified:	20 May 2017 05:05
URI:	http://eprints.iisc.ac.in/id/eprint/56882

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