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Cyclo(L-leucyl-$\alpha$,$\beta$-dehydrophenylalanine): the first diketopiperazine containing an $\alpha$,$\beta$-dehydrophenylalanine residue

Bagaria, A and Ramakumar, S and Gupta, M and Chauhan, VS (2005) Cyclo(L-leucyl-$\alpha$,$\beta$-dehydrophenylalanine): the first diketopiperazine containing an $\alpha$,$\beta$-dehydrophenylalanine residue. In: Acta crystallographica. Section C, Crystal structure communications, 61 (3). pp. 174-176.

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The title compound (systematic name: 3-benzylidene-6-isobutylpiperazine-2,5-dione), $C_1_5H_1_8N_2O_2$, an $\alpha$,$\beta$-dehydrophenylalanine containing diketopiperazine, crystallizes in the space group P1 with two molecules in the asymmetric unit arranged antiparallel to one another. The $\alpha$,$\beta$-dehydrophenylalanine ($\Delta$Phe) residue in this cyclic peptide retains its planarity but deviates from the standard conformations observed in its linear analogues. Each type of molecule forms a linear chain with molecules of the same type via pairwise N-H \cdot\cdot\cdot O hydrogen bonds, while weaker C-H \cdot\cdot\cdot O interactions link the chains together to form a three-dimensional network.

Item Type: Journal Article
Additional Information: The copyright belongs to International Union of Crystallography.
Department/Centre: Division of Information Sciences (Doesn't exist now) > BioInformatics Centre
Division of Physical & Mathematical Sciences > Physics
Depositing User: Nagaraj Vaidya
Date Deposited: 27 Feb 2006
Last Modified: 19 Sep 2010 04:24
URI: http://eprints.iisc.ac.in/id/eprint/5671

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