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Total Synthesis of the Bis-silyl Ether of (+)-15-epi-Aetheramide A

Revu, Omkar and Prasad, Kavirayani R (2017) Total Synthesis of the Bis-silyl Ether of (+)-15-epi-Aetheramide A. In: JOURNAL OF ORGANIC CHEMISTRY, 82 (1). pp. 438-460.

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Official URL: http://dx.doi.org/10.1021/acs.joc.6b02535

Abstract

Synthesis of the macrolactone depsipeptide aetheramide A was attempted by three different approaches. The first approach to form the macrolactone involving macrolactonization to form the C1-C21 bond and the second approach using a ring-closing metathesis (RCM) strategy to form the C10-C11 olefinic bond failed. The third approach starting from R-mandelic acid, involving the RCM reaction to install the C18-C19 ring junction, was successful in assembling the macrolactone.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Depositing User: Id for Latest eprints
Date Deposited: 08 Mar 2017 09:10
Last Modified: 08 Mar 2017 09:10
URI: http://eprints.iisc.ac.in/id/eprint/56289

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