Quantitative vibro-acoustography of tissue-like objects by measurement of resonant modes

Mazumder, Dibbyan and Umesh, Sharath and Vasu, Ram Mohan and Roy, Debasish and Kanhirodan, Rajan and Asokan, Sundarrajan (2017) Quantitative vibro-acoustography of tissue-like objects by measurement of resonant modes. In: PHYSICS IN MEDICINE AND BIOLOGY, 62 (1). pp. 107-126.

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Abstract

We demonstrate a simple and computationally efficient method to recover the shear modulus pertaining to the focal volume of an ultrasound transducer from the measured vibro-acoustic spectral peaks. A model that explains the transport of local deformation information with the acoustic wave acting as a carrier is put forth. It is also shown that the peaks correspond to the natural frequencies of vibration of the focal volume, which may be readily computed by solving an eigenvalue problem associated with the vibrating region. Having measured the first natural frequency with a fibre Bragg grating sensor, and armed with an expedient means of computing the same, we demonstrate a simple procedure, based on the method of bisection, to recover the average shear modulus of the object in the ultrasound focal volume. We demonstrate this recovery for four homogeneous agarose slabs of different stiffness and verify the accuracy of the recovery using independent rheometer-based measurements. Extension of the method to anisotropic samples through the measurement of a more complete set of resonant modes and the recovery of an elasticity tensor distribution, as is done in resonant ultrasound spectroscopy, is suggested.

Item Type:	Journal Article
Publication:	PHYSICS IN MEDICINE AND BIOLOGY
Additional Information:	Copy right for this article belongs to the IOP PUBLISHING LTD, TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
Keywords:	biomedical imaging; elastic recovery; image reconstruction; inverse problem; ultrasonic imaging
Department/Centre:	Division of Mechanical Sciences > Civil Engineering Division of Physical & Mathematical Sciences > Instrumentation Appiled Physics Division of Physical & Mathematical Sciences > Physics
Date Deposited:	10 Feb 2017 09:46
Last Modified:	10 Feb 2017 09:46
URI:	http://eprints.iisc.ac.in/id/eprint/56213

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