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Sensing of insulin fibrillation using alkoxy-bridged binuclear rhenium(I) complexes

Sathish, Veerasamy and Ramdass, Arumugam and Lu, Zong-Zhan and Velayudham, Murugesan and Thanasekaran, Pounraj and Lu, Kuang-Lieh and Rajagopal, Seenivasan (2016) Sensing of insulin fibrillation using alkoxy-bridged binuclear rhenium(I) complexes. In: INORGANIC CHEMISTRY COMMUNICATIONS, 73 . pp. 49-51.

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Official URL: http://dx.doi.org/10.1016/j.inoche.2016.09.015


For the first time we report the simple, cost-effective, sensitive detection of human insulin fibrils using an alkoxy-bridged binuclear rhenium(I) complexes by the enhancement in luminescence intensity, emission lifetime and the formation of fibrils. The Re(I) complexes are weakly emissive, when it is dissolved with native insulin in an incubation buffer, but it becomes highly luminescent after the formation of insulin fibrils. This binding of human insulin fibrils is attributed to the hydrophobic as well as pi - pi stacking interaction of naphthalene moiety present in rhenium(I) complexes. (C) 2016 Elsevier B.V. All rights reserved.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
Department/Centre: Division of Chemical Sciences > Inorganic & Physical Chemistry
Depositing User: Id for Latest eprints
Date Deposited: 07 Dec 2016 05:52
Last Modified: 07 Dec 2016 05:52
URI: http://eprints.iisc.ac.in/id/eprint/55543

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