Modulated in Vitro Biocompatibility of a Unique Cross-Linked Salicylic Acid-Poly(epsilon-caprolactone)-Based Biodegradable Polymer

Bhaskar, Nitu and Padmavathy, Nagarajan and Jain, Shubham and Bose, Suryasarathi and Basu, Bikramjit (2016) Modulated in Vitro Biocompatibility of a Unique Cross-Linked Salicylic Acid-Poly(epsilon-caprolactone)-Based Biodegradable Polymer. In: ACS APPLIED MATERIALS & INTERFACES, 8 (43). pp. 29721-29733.

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Abstract

Herein, we report the development of a unique architecture by chemically cross-linking salicylic acid (SA)-based poly(anhydride ester) onto a biodegradable amine-functionalized poly(caprolactone) (PCL), using lactic acid as a spacer. The ester and amide linkages in the SA PCL polymer, synthesized through melt condensation, were confirmed by NMR and FT-IR spectroscopic techniques. The enzymatic and nonenzymatic hydrolytic degradation profile exhibited linear degradation kinetics over an extended time period (>5 weeks). The compatibility and growth of C2C12 myoblast cells were found to be significantly improved on the fast-degrading SA PCL substrates compared to those over neat PCL and amine-functionalized PCL. Further, the decreased red blood cell damage, illustrated by 0.39% hemolysis activity and a minimal number of platelet adhesion on a SA PCL polymeric surface confirmed good hemocompatibility of the as-synthesized polymer. Together with a moderate bactericidal property, the spectrum of properties of this novel polymer can be attributed to the synergistic effect of the presence of chemical moieties of SA and amine groups in PCL. In summary, it is considered that a SA PCL-based cross-linked composite can be utilized as a new biodegradable polymer.

Item Type:	Journal Article
Publication:	ACS APPLIED MATERIALS & INTERFACES
Additional Information:	Copy right for this article belongs to the AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
Department/Centre:	Division of Chemical Sciences > Materials Research Centre Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited:	21 Dec 2016 07:26
Last Modified:	11 Oct 2018 14:20
URI:	http://eprints.iisc.ac.in/id/eprint/55534

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