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Chemistry and Biology in the Biosynthesis and Action of Thyroid Hormones

Mondal, Santanu and Raja, Karuppusamy and Schweizer, Ulrich and Mugesh, Govindasamy (2016) Chemistry and Biology in the Biosynthesis and Action of Thyroid Hormones. In: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 55 (27). pp. 7606-7630.

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Official URL: http://dx.doi.org/10.1002/anie.201601116

Abstract

Thyroid hormones (THs) are secreted by the thyroid gland. They control lipid, carbohydrate, and protein metabolism, heart rate, neural development, as well as cardiovascular, renal, and brain functions. The thyroid gland mainly produces l-thyroxine (T4) as a prohormone, and 5'-deiodination of T4 by iodothyronine deiodinases generates the nuclear receptor binding hormone T3. In this Review, we discuss the basic aspects of the chemistry and biology as well as recent advances in the biosynthesis of THs in the thyroid gland, plasma transport, and internalization of THs in their target organs, in addition to the deiodination and various other enzyme-mediated metabolic pathways of THs. We also discuss thyroid hormone receptors and their mechanism of action to regulate gene expression, as well as various thyroid-related disorders and the available treatments.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the WILEY-V C H VERLAG GMBH, POSTFACH 101161, 69451 WEINHEIM, GERMANY
Department/Centre: Division of Chemical Sciences > Inorganic & Physical Chemistry
Depositing User: Id for Latest eprints
Date Deposited: 28 Oct 2016 06:57
Last Modified: 28 Oct 2016 06:57
URI: http://eprints.iisc.ac.in/id/eprint/55108

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