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Magnetically active micromixer assisted synthesis of drug nanocomplexes exhibiting strong bactericidal potential

Veldurthi, Naresh and Ghoderao, Prachi and Sahare, Sanjay and Kumar, Vijay and Bodas, Dhananjay and Kulkarni, Anjali and Bhave, Tejashree (2016) Magnetically active micromixer assisted synthesis of drug nanocomplexes exhibiting strong bactericidal potential. In: MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 68 . pp. 455-464.

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Official URL: http://dx.doi.org/10.1016/j.msec.2016.06.015

Abstract

In the ever-growing demand for drug nanocomplexes (DNCs), the need for smart systems or processes is indispensable to circumvent the demerits imposed by the conventional methods for the synthesis of DNCs. The demerits include prolonged hours of the synthesis, minimal loading and poor conjugation. Herein, we proposed a simplistic approach for the synthesis of DNCs through a magnetically active Polydimethylsiloxane micromixer which can render maximal loading in an unprecedented time. The UV-Vis, FTIR, and XRD analysis corroborate the proposed mechanism of conjugation of the drug and nanoparticles. The XPS, contact angle and zeta potential measurements revealed the composition, hydrophilicity and surface charges of the synthesized DNCs, respectively. Further, the microscopy images exemplify the encapsulation of the drug. In the antibacterial activity studies, the DNCs substantially inhibited the growth of the Staphylococcus aureus bacteria. FESEM images proved preferential accumulation of DNCs around bacterial cells effectively annihilating them. (C) 2016 Elsevier B.V. All rights reserved.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
Department/Centre: Division of Interdisciplinary Research > Centre for Nano Science and Engineering
Depositing User: Id for Latest eprints
Date Deposited: 28 Oct 2016 06:55
Last Modified: 28 Oct 2016 06:55
URI: http://eprints.iisc.ac.in/id/eprint/55069

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