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Synthesis of alpha-sulfenyl monoketones via a metal-free oxidative cross dehydrogenative coupling (CDC) reaction

Varun, Begur Vasanthkumar and Gadde, Karthik and Prabhu, Kandikere Ramaiah (2016) Synthesis of alpha-sulfenyl monoketones via a metal-free oxidative cross dehydrogenative coupling (CDC) reaction. In: ORGANIC & BIOMOLECULAR CHEMISTRY, 14 (32). pp. 7665-7670.

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Official URL: http://dx.doi.org/10.1039/c6ob01243d

Abstract

alpha-Sulfenyl ketones are potential precursors which find a variety of applications in organic synthesis. Their typical synthesis requires pre-functionalized starting materials and two to three step synthetic sequences. In addition, the selective pre-functionalization of unsymmetrical ketones is a challenge, which limits the synthesis of the desired sulfenylated ketones. To overcome these disadvantages, a metal-free, convenient one-step strategy for synthesizing alpha-sulfenyl ketones at ambient temperature via a cross-dehydrogenative coupling (CDC) strategy has been developed with a broad substrate scope. Therefore, this CDC strategy for C-S bond formation is attractive and may find wide applications in organic synthesis.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Depositing User: Id for Latest eprints
Date Deposited: 22 Oct 2016 09:12
Last Modified: 22 Oct 2016 09:12
URI: http://eprints.iisc.ac.in/id/eprint/54989

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