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Computational recognition and analysis of hitherto uncharacterized nucleotide cyclase-like proteins in bacteria

Ramakrishnan, Gayatri and Jain, Abha and Chandra, Nagasuma and Srinivasan, Narayanaswamy (2016) Computational recognition and analysis of hitherto uncharacterized nucleotide cyclase-like proteins in bacteria. In: BIOLOGY DIRECT, 11 .

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Official URL: http://dx.doi.org/10.1186/s13062-016-0130-9

Abstract

Evolutionary relationship between class III nucleotide cyclases and an uncharacterized set of bacterial proteins from Actinobacteria, Bacteroidetes and Proteobacteria has been recognized and analyzed. Detailed analyses of sequence and structural features resulted in the recognition of potential cyclase function conferring residues and presence of signature topological motif (beta aa beta beta a beta) in the uncharacterized set of bacterial proteins. Lack of transmembrane domains and signal peptide cleavage sites is suggestive of their cytosolic subcellular localization. Furthermore, analysis on evolutionarily conserved gene clusters of the predicted nucleotide cyclase-like proteins and their evolutionary relationship with nucleotide cyclases suggest their participation in cellular signalling events. Our analyses suggest expansion of class III nucleotide cyclases.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the BIOMED CENTRAL LTD, 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
Keywords: Distant relationship; Domain of unknown function; Mycobacteria; Nucleotide cyclase; Protein evolution; Sequence analysis
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Depositing User: Id for Latest eprints
Date Deposited: 30 Jun 2016 04:57
Last Modified: 25 Oct 2018 09:34
URI: http://eprints.iisc.ac.in/id/eprint/54089

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