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Muscles provide protection during microbial infection by activating innate immune response pathways in Drosophila and zebrafish

Chatterjee, Arunita and Roy, Debasish and Patnaik, Esha and Nongthomba, Upendra (2016) Muscles provide protection during microbial infection by activating innate immune response pathways in Drosophila and zebrafish. In: DISEASE MODELS & MECHANISMS, 9 (6). pp. 697-705.

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Official URL: http://dx.doi.org/10.1242/dmm.022665

Abstract

Muscle contraction brings about movement and locomotion in animals. However, muscles have also been implicated in several atypical physiological processes including immune response. The role of muscles in immunity and the mechanism involved has not yet been deciphered. In this paper, using Drosophila indirect flight muscles (IFMs) as a model, we show that muscles are immune-responsive tissues. Flies with defective IFMs are incapable of mounting a potent humoral immune response. Upon immune challenge, the IFMs produce anti-microbial peptides (AMPs) through the activation of canonical signaling pathways, and these IFM-synthesized AMPs are essential for survival upon infection. The trunk muscles of zebrafish, a vertebrate model system, also possess the capacity to mount an immune response against bacterial infections, thus establishing that immune responsiveness of muscles is evolutionarily conserved. Our results suggest that physiologically fit muscles might boost the innate immune response of an individual.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the COMPANY OF BIOLOGISTS LTD, BIDDER BUILDING CAMBRIDGE COMMERCIAL PARK COWLEY RD, CAMBRIDGE CB4 4DL, CAMBS, ENGLAND
Keywords: Muscle; Drosophila; Zebrafish; Infection; Immunity; Anti-microbial peptides
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Depositing User: Id for Latest eprints
Date Deposited: 30 Jun 2016 05:26
Last Modified: 30 Jun 2016 05:26
URI: http://eprints.iisc.ac.in/id/eprint/54084

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