ePrints@IIScePrints@IISc Home | About | Browse | Latest Additions | Advanced Search | Contact | Help

A gallic acid-succinimide co-crystal landscape: polymorphism, pseudopolymorphism, variable stoichiometry co-crystals and concomitant growth of non-solvated and solvated co-crystals

Kaur, Ramanpreet and Cherukuvada, Suryanarayan and Managutti, Praveen B and Row, Tayur Guru N (2016) A gallic acid-succinimide co-crystal landscape: polymorphism, pseudopolymorphism, variable stoichiometry co-crystals and concomitant growth of non-solvated and solvated co-crystals. In: CRYSTENGCOMM, 18 (18). pp. 3191-3203.

[img] PDF
Cry_Eng_Com_18-18_3191_2016.pdf - Published Version
Restricted to Registered users only

Download (5MB) | Request a copy
Official URL: http://dx.doi.org/10.1039/c5ce01965f

Abstract

The structural landscape of the binary gallic acid-succinimide combination has been explored. A recently reported dimorphic 1 : 2 co-crystal was shown to exhibit a third polymorph at a high temperature by differential scanning calorimetry (DSC). Further, seven solvated co-crystals have been obtained, including three different hydrates (gallic acid : succinimide : water in 1 : 1 : 1, 2 : 2 : 1 & 2 : 4 : 1 ratios) and solvates with 1,4-dioxane (1 : 1 : 1), tetrahydrofuran (2 : 2 : 1), acetone (2 : 2 : 1) and ethyl acetate (3 : 3 : 1). A rare phenomenon of concomitant solvation, besides concomitant polymorphism, in the 1 : 2 co-crystal is recognized, which posed difficulties in obtaining phase-pure crystal forms in bulk quantity. Based on structural insights, methods to obtain pure co-crystals and design of several solvates are suggested. Additionally, a 1 : 1 co-crystal, which had been elusive under ambient conditions, is found to show polymorphic behavior for the materials obtained under nitrogen atmosphere and by high temperature desolvation of several solvates as analyzed by powder X-ray diffraction (PXRD) and DSC.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
Department/Centre: Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Depositing User: Id for Latest eprints
Date Deposited: 17 Jun 2016 05:05
Last Modified: 17 Jun 2016 05:05
URI: http://eprints.iisc.ac.in/id/eprint/53985

Actions (login required)

View Item View Item