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Protein sequence design and its applications

Sandhya, Sankaran and Mudgal, Richa and Kumar, Gayatri and Sowdhamini, Ramanathan and Srinivasan, Narayanaswamy (2016) Protein sequence design and its applications. In: CURRENT OPINION IN STRUCTURAL BIOLOGY, 37 . pp. 71-80.

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Official URL: http://dx.doi.org/10.1016/j.sbi.2015.12.004

Abstract

Design of proteins has far-reaching potentials in diverse areas that span repurposing of the protein scaffold for reactions and substrates that they were not naturally meant for, to catching a glimpse of the ephemeral proteins that nature might have sampled during evolution. These non-natural proteins, either in synthesized or virtual form have opened the scope for the design of entities that not only rival their natural counterparts but also offer a chance to visualize the protein space continuum that might help to relate proteins and understand their associations. Here, we review the recent advances in protein engineering and design, in multiple areas, with a view to drawing attention to their future potential.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the CURRENT BIOLOGY LTD, 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Depositing User: Id for Latest eprints
Date Deposited: 11 Jun 2016 07:51
Last Modified: 16 Oct 2018 09:14
URI: http://eprints.iisc.ac.in/id/eprint/53905

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