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Epigenetics and miRNA during bacteria-induced host immune responses

Holla, Sahana and Balaji, Kithiganahalli Narayanaswamy (2015) Epigenetics and miRNA during bacteria-induced host immune responses. In: EPIGENOMICS, 7 (7). pp. 1197-1212.

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Official URL: http://dx.doi.org/10.2217/epi.15.75

Abstract

Various cellular processes including the pathogen-specific immune responses, host-pathogen interactions and the related evasion mechanisms rely on the ability of the immune cells to be reprogrammed accurately and in many cases instantaneously. In this context, the exact functions of epigenetic and miRNA-mediated regulation of genes, coupled with recent advent in techniques that aid such studies, make it an attractive field for research. Here, we review examples that involve the epigenetic and miRNA control of the host immune system during infection with bacteria. Interestingly, many pathogens utilize the epigenetic and miRNA machinery to modify and evade the host immune responses. Thus, we believe that global epigenetic and miRNA mapping of such host-pathogen interactions would provide key insights into their cellular functions and help to identify various determinants for therapeutic value.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the FUTURE MEDICINE LTD, UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3 1QB, ENGLAND
Keywords: DNA methylation; epigenetics; histone modification; host-pathogen interactions; immune responses; miRNA
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Depositing User: Id for Latest eprints
Date Deposited: 14 Jan 2016 06:14
Last Modified: 14 Jan 2016 06:14
URI: http://eprints.iisc.ac.in/id/eprint/53102

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