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Synthesis, ABTS-Radical Scavenging Activity, and Antiproliferative and Molecular Docking Studies of Novel Pyrrolo1,2-a]quinoline Derivatives

Nanjappa, Chandrika and Hanumanthappa, Suresha Kumara T and Nagendrappa, Gopalpur and Ganapathy, Pasura Subbaiah Sujan and Shruthi, Shirur Dakappa and More, Sunil S and Jose, Gilish and Sowmya, HBV and Kulkarni, Rashmi S (2015) Synthesis, ABTS-Radical Scavenging Activity, and Antiproliferative and Molecular Docking Studies of Novel Pyrrolo1,2-a]quinoline Derivatives. In: SYNTHETIC COMMUNICATIONS, 45 (22). pp. 2529-2545.

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Official URL: http://dx.doi.org/10.1080/00397911.2015.1085572 ...

Abstract

A new 2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS)-radical scavenging and antiproliferative agents of pyrrolo1,2-a]quinoline derivatives have been synthesized. An efficient method for the synthesis of 14 novel diversified pyrrolo1,2-a]quinoline derivatives has been described using 4-(1,3-dioxolan-2-yl)quinoline and different phenacyl bromides in acetone and followed by reacting with different acetylenes in dimethylformamide/K2CO3. The structure of the newly synthesized compounds was determined by infrared, H-1 NMR, C-13 NMR, mass spectrometry, and elemental analysis. The in vitro antioxidant activity revealed that among all the tested compounds 5n exhibited maximum scavenging activity with ABTS. Compound 5b has showed good antiproliferative activity as an inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the TAYLOR & FRANCIS INC, 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
Keywords: ABTS-radical scavenging activity; antiproliferative activity; 1; 3-dipolar cycloaddition; molecular docking; pyrrolo1; 2-a]quinoline; quinoline 4-carbaldehyde
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Depositing User: Id for Latest eprints
Date Deposited: 30 Dec 2015 06:07
Last Modified: 30 Dec 2015 06:07
URI: http://eprints.iisc.ac.in/id/eprint/52969

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