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Cybernetic Modeling Revisited: A Method for Inferring the Cybernetic Variables u(i) from Experimental Data

Mandli, Aravinda R and Modak, Jayant M (2015) Cybernetic Modeling Revisited: A Method for Inferring the Cybernetic Variables u(i) from Experimental Data. In: INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 54 (42). pp. 10190-10196.

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Official URL: http://dx.doi.org/10.1021/acs.iecr.5b00306

Abstract

The cybernetic modeling framework for the growth of microorganisms provides for an elegant methodology to account for the unknown regulatory phenomena through the use of cybernetic variables for enzyme induction and activity. In this paper, we revisit the assumption of limited resources for enzyme induction (Sigma u(i) = 1) used in the cybernetic modeling framework by presenting a methodology for inferring the individual cybernetic variables u(i) from experimental data. We use this methodology to infer u(i) during the simultaneous consumption of glycerol and lactose by Escherichia coli and then model the fitness trade-offs involved in the recently discovered predictive regulation strategy of microorganisms.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
Department/Centre: Division of Mechanical Sciences > Chemical Engineering
Depositing User: Id for Latest eprints
Date Deposited: 24 Nov 2015 06:02
Last Modified: 24 Nov 2015 06:02
URI: http://eprints.iisc.ac.in/id/eprint/52811

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