ePrints@IIScePrints@IISc Home | About | Browse | Latest Additions | Advanced Search | Contact | Help

Insights into the catalytic mechanism of synthetic glutathione peroxidase mimetics

Bhowmick, Debasish and Mugesh, Govindasamy (2015) Insights into the catalytic mechanism of synthetic glutathione peroxidase mimetics. In: ORGANIC & BIOMOLECULAR CHEMISTRY, 13 (41). pp. 10262-10272.

[img] PDF
Org_Bio_Che_13-41-10262_2015.pdf - Published Version
Restricted to Registered users only

Download (934kB) | Request a copy
Official URL: http://dx.doi.org/10.1039/c5ob01665g

Abstract

Glutathione Peroxidase (GPx) is a key selenoenzyme that protects biomolecules from oxidative damage. Extensive research has been carried out to design and synthesize small organoselenium compounds as functional mimics of GPx. While the catalytic mechanism of the native enzyme itself is poorly understood, the synthetic mimics follow different catalytic pathways depending upon the structures and reactivities of various intermediates formed in the catalytic cycle. The steric as well as electronic environments around the selenium atom not only modulate the reactivity of these synthetic mimics towards peroxides and thiols, but also the catalytic mechanisms. The catalytic cycle of small GPx mimics is also dependent on the nature of peroxides and thiols used in the study. In this review, we discuss how the catalytic mechanism varies with the substituents attached to the selenium atom.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
Department/Centre: Division of Chemical Sciences > Inorganic & Physical Chemistry
Depositing User: Id for Latest eprints
Date Deposited: 19 Nov 2015 04:57
Last Modified: 19 Nov 2015 04:57
URI: http://eprints.iisc.ac.in/id/eprint/52790

Actions (login required)

View Item View Item