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Heat Shock Protein 90 regulates encystation in Entamoeba

Singh, Meetali and Sharma, Shalini and Bhattacharya, Alok and Tatu, Utpal (2015) Heat Shock Protein 90 regulates encystation in Entamoeba. In: FRONTIERS IN MICROBIOLOGY, 6 .

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Official URL: http://dx.doi.org/10.3389/fmicb.2015.01125

Abstract

Enteric protozoan Entamoeba histolytica is a major cause of debilitating diarrheal infection worldwide with high morbidity and mortality. Even though the clinical burden of this parasite is very high, this infection is categorized as a neglected disease. Parasite is transmitted through feco-oral route and exhibit two distinct stages namely - trophozoites and cysts. Mechanism and regulation of encystation is not clearly understood. Previous studies have established the role of Heat shock protein 90 (Hsp90) in regulating stage transition in various protozoan parasites like Giardia, Plasmodium, Leishmania, and Toxoplasma. Our study for the first time reports that Hsp90 plays a crucial role in life cycle of Entamoeba as well. We identify Hsp90 to be a negative regulator of encystation in Entamoeba. We also show that Hsp90 inhibition interferes with the process of phagocytosis in Entamoeba. Overall, we show that Hsp90 plays an important role in virulence and transmission of Entamoeba.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the FRONTIERS MEDIA SA, PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND
Keywords: Entamoaba; Hsp90; phagocytosis; encystation; 17-AAG; Cyst
Department/Centre: Division of Biological Sciences > Biochemistry
Depositing User: Id for Latest eprints
Date Deposited: 19 Nov 2015 04:49
Last Modified: 19 Nov 2015 04:49
URI: http://eprints.iisc.ac.in/id/eprint/52765

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