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Synthesis of Optically Active 2-Amino-1,3,4-oxadiazoles and their Hybrid Peptides

Madhu, Chilakapati and Prabhu, Girish and Pal, Rumpa and Row, Guru TN and Sureshbabu, Vommina V (2015) Synthesis of Optically Active 2-Amino-1,3,4-oxadiazoles and their Hybrid Peptides. In: JOURNAL OF HETEROCYCLIC CHEMISTRY, 52 (5). pp. 1438-1446.

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Official URL: http://dx.doi.org/10.1002/jhet.2166


Synthesis of 2-amino-1,3,4-oxadiazole derivatives of N-Cbz(benzyloxycarbonyl)/Boc-protected amino/peptide acids under sonication is described. The conditions involved in the present protocol are simple, mild, and racemization free. The utility of 2-amino group in the substituted oxadiazoles for the incorporation of peptide and ureido bonds to obtain hybrid peptidomimetics is also delineated. The 2-amino-1,3,4-oxadiazole 3b was obtained as a single crystal, and its molecular structure has been confirmed through X-ray crystallographic study.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the WILEY-BLACKWELL, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
Department/Centre: Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Date Deposited: 30 Oct 2015 06:55
Last Modified: 30 Oct 2015 06:55
URI: http://eprints.iisc.ac.in/id/eprint/52649

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