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Snaps and mends: DNA breaks and chromosomal translocations

Javadekar, Saniya M and Raghavan, Sathees C (2015) Snaps and mends: DNA breaks and chromosomal translocations. In: FEBS JOURNAL, 282 (14). pp. 2627-2645.

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Official URL: http://dx.doi.org/10.1111/febs.13311

Abstract

Integrity in entirety is the preferred state of any organism. The temporal and spatial integrity of the genome ensures continued survival of a cell. DNA breakage is the first step towards creation of chromosomal translocations. In this review, we highlight the factors contributing towards the breakage of chromosomal DNA. It has been well-established that the structure and sequence of DNA play a critical role in selective fragility of the genome. Several non-B-DNA structures such as Z-DNA, cruciform DNA, G-quadruplexes, R loops and triplexes have been implicated in generation of genomic fragility leading to translocations. Similarly, specific sequences targeted by proteins such as Recombination Activating Genes and Activation Induced Cytidine Deaminase are involved in translocations. Processes that ensure the integrity of the genome through repair may lead to persistence of breakage and eventually translocations if their actions are anomalous. An insufficient supply of nucleotides and chromatin architecture may also play a critical role. This review focuses on a range of events with the potential to threaten the genomic integrity of a cell, leading to cancer.

Item Type: Journal Article
Additional Information: Copy right of this article belongs to the WILEY-BLACKWELL, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
Keywords: AID; chromosomal translocations; DSBs (DNA double strand breaks); DNA Repair; Chromatin architecture; genomic instability; leukaemia; lymphoma; non-B-DNA structures; RAGs
Department/Centre: Division of Biological Sciences > Biochemistry
Depositing User: Id for Latest eprints
Date Deposited: 03 Sep 2015 06:20
Last Modified: 03 Sep 2015 06:20
URI: http://eprints.iisc.ac.in/id/eprint/52297

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