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Lateralisation abnormalities in obsessive-compulsive disorder: a line bisection study

Rao, Naren Prahlada and Arasappa, Rashmi and Reddy, Nalini Narayana and Venkatasubramanian, Ganesan and Reddy, Janardhan YC (2015) Lateralisation abnormalities in obsessive-compulsive disorder: a line bisection study. In: ACTA NEUROPSYCHIATRICA, 27 (4). pp. 242-247.

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Official URL: http://dx.doi.org/10.1017/neu.2015.23

Abstract

Objective Asymmetry in brain structure and function is implicated in the pathogenesis of psychiatric disorders. Although right hemisphere abnormality has been documented in obsessive-compulsive disorder (OCD), cerebral asymmetry is rarely examined. Therefore, in this study, we examined anomalous cerebral asymmetry in OCD patients using the line bisection task. Methods A total of 30 patients with OCD and 30 matched healthy controls were examined using a reliable and valid two-hand line bisection (LBS) task. The comparative profiles of LBS scores were analysed using analysis of covariance. Results Patients with OCD bisected significantly less number of lines to the left and had significant rightward deviation than controls, indicating right hemisphere dysfunction. The correlations observed in this study suggest that those with impaired laterality had more severe illness at baseline. Conclusions The findings of this study indicate abnormal cerebral lateralisation and right hemisphere dysfunction in OCD patients.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the CAMBRIDGE UNIV PRESS, 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
Keywords: asymmetry; laterality; line bisection; obsessive-compulsive disorder; right hemisphere
Department/Centre: Division of Biological Sciences > Centre for Neuroscience
Depositing User: Id for Latest eprints
Date Deposited: 04 Aug 2015 09:28
Last Modified: 04 Aug 2015 09:28
URI: http://eprints.iisc.ac.in/id/eprint/52019

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