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Synthesis and evaluation of the biological activity of N `-2-oxo-1,2 dihydro-3H-indol-3-ylidene] benzohydrazides as potential anticancer agents

Katiyar, Arpit and Hegde, Mahesh and Kumar, Sujeet and Gopalakrishnan, Vidya and Bhatelia, Khyati D and Ananthaswamy, Kavya and Ramareddy, Sureshbabu A and De Clercq, Erik and Choudhary, Bibha and Schols, Dominique and Raghavan, Sathees C and Karki, Subhas S (2015) Synthesis and evaluation of the biological activity of N `-2-oxo-1,2 dihydro-3H-indol-3-ylidene] benzohydrazides as potential anticancer agents. In: RSC ADVANCES, 5 (56). pp. 45492-45501.

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Official URL: http://dx.doi.org/ 10.1039/c5ra01528f

Abstract

New N'-2-oxo-1,2-dihydro-3H-indol-3-ylidene]benzohydrazide derivatives were synthesized and evaluated for their cytotoxic properties against murine leukemia, L1210, human leukemia, REH and K562, human T-cell leukemia, CEM and human cervix carcinoma, HeLa cells. Among the tested compounds, the 3,4,5-trimethoxy-N'-5-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]ben zohydrazide derivative (5t) emerged as the most potent inhibitor against all the tumor cell lines evaluated. To investigate the mechanism of action, 5t was further studied by cell cycle analysis, mitochondrial membrane potential analysis, DNA fragmentation and Annexin V-FITC flow cytometric analysis, which suggested that 5t was able to induce apoptosis at submicromolar range.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
Department/Centre: Division of Biological Sciences > Biochemistry
Depositing User: Id for Latest eprints
Date Deposited: 06 Jul 2015 05:36
Last Modified: 06 Jul 2015 05:36
URI: http://eprints.iisc.ac.in/id/eprint/51791

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