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Challenges in the quantification and interpretation of spike-LFP relationships

Ray, Supratim (2015) Challenges in the quantification and interpretation of spike-LFP relationships. In: CURRENT OPINION IN NEUROBIOLOGY, 31 . pp. 111-118.

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Official URL: http://dx.doi.org/10.1016/j.conb.2014.09.004

Abstract

Brain signals often show fluctuations in particular frequency bands, which are highly conserved across species and are associated with specific behavioural states. Such rhythmic patterns can be captured in the local field potential (LFP), which is obtained by low-pass filtering the extracellular signal recorded from microelectrodes. However, LFP also captures other neural processes that are associated with spikes, such as synaptic events preceding a spike, low-frequency component of the action potential (spike bleed-through'') and spike afterhyperpolarization, which pose difficulties in the estimation of the amplitude and phase of the rhythm with respect to spikes. Here we discuss these issues and different techniques that have been used to dissociate the rhythm from other neural events in the LFP.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the CURRENT BIOLOGY LTD, 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
Keywords: LOCAL-FIELD POTENTIALS; PRIMARY VISUAL-CORTEX; GAMMA-OSCILLATIONS; FUNCTIONAL CONNECTIVITY; TEMPORAL STRUCTURE; HIPPOCAMPUS; NETWORKS; RHYTHMS; RECORDINGS; MECHANISMS
Department/Centre: Division of Biological Sciences > Centre for Neuroscience
Depositing User: Id for Latest eprints
Date Deposited: 13 May 2015 07:02
Last Modified: 13 May 2015 07:02
URI: http://eprints.iisc.ac.in/id/eprint/51516

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