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Insulin-Like Growth Factor System in Cancer: Novel Targeted Therapies

Brahmkhatri, Varsha P and Prasanna, Chinmayi and Atreya, Hanudatta S (2015) Insulin-Like Growth Factor System in Cancer: Novel Targeted Therapies. In: BIOMED RESEARCH INTERNATIONAL .

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Official URL: http://dx.doi.org/10.1155/2015/538019

Abstract

Insulin-like growth factors (IGFs) are essential for growth and survival that suppress apoptosis and promote cell cycle progression, angiogenesis, and metastatic activities in various cancers. The IGFs actions are mediated through the IGF-1 receptor that is involved in cell transformation induced by tumour. These effects depend on the bioavailability of IGFs, which is regulated by IGF binding proteins (IGFBPs). We describe here the role of the IGF system in cancer, proposing new strategies targeting this system. We have attempted to expand the general viewpoint on IGF-1R, its inhibitors, potential limitations of IGF-1R, antibodies and tyrosine kinase inhibitors, and IGFBP actions. This review discusses the emerging view that blocking IGF via IGFBP is a better option than blocking IGF receptors. This can lead to the development of novel cancer therapies.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the HINDAWI PUBLISHING CORPORATION, 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
Keywords: FACTOR-I RECEPTOR; FACTOR-BINDING PROTEIN-2; MANNOSE 6-PHOSPHATE RECEPTOR; SMOOTH-MUSCLE-CELLS; MESSENGER RIBONUCLEIC-ACIDS; GENE-EXPRESSION PROFILES; LONGITUDINAL BONE-GROWTH; PROTEASE-RESISTANT FORM; INHIBITS TUMOR-GROWTH; C-TERMINAL DOMAIN
Department/Centre: Division of Chemical Sciences > NMR Research Centre (Formerly Sophisticated Instruments Facility)
Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Depositing User: Id for Latest eprints
Date Deposited: 06 May 2015 05:32
Last Modified: 06 May 2015 05:32
URI: http://eprints.iisc.ac.in/id/eprint/51499

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