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A CONVENIENT MODIFICATION OF THE FISCHER INDOLE SYNTHESIS WITH A SOLID ACID

Chandrasekhar, Sosale and Mukherjee, Somnath (2015) A CONVENIENT MODIFICATION OF THE FISCHER INDOLE SYNTHESIS WITH A SOLID ACID. In: SYNTHETIC COMMUNICATIONS, 45 (8). pp. 1018-1022.

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Official URL: http://dx.doi.org/10.1080/00397911.2014.984854

Abstract

A new one-pot version of the titled reaction involves heating a mixture of a carbonyl compound, a phenylhydrazine, and the cation exchange resin Amberlite IR 120 in refluxing ethanol. A variety of enolizable aldehydes, and ketones and several substituted phenylhydrazines could thus be converted to the corresponding indoles in excellent yields (70-88%). Reaction times were typically 6-10 h, with the resin being then filtered off and the product isolated after minimal workup.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the TAYLOR & FRANCIS INC, 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
Keywords: Hydrazine; ion exchange; polymer support
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Depositing User: Id for Latest eprints
Date Deposited: 24 Apr 2015 06:22
Last Modified: 24 Apr 2015 06:22
URI: http://eprints.iisc.ac.in/id/eprint/51409

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