Organocatalytic Enantioselective Formal C(sp(2))-H Alkylation

Manna, Madhu Sudan and Mukherjee, Santanu (2015) Organocatalytic Enantioselective Formal C(sp(2))-H Alkylation. In: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 137 (1). pp. 130-133.

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Abstract

An organocatalytic enantioselective formal C(sp(2))-H alkylation is reported. This alkylative desymmetrization of prochiral 2,2-disubstituted cyclopentene-1,3-dione is catalyzed by a bifunctional tertiary aminourea derivative, utilizes air-stable and inexpensive nitroalkanes as the alkylating agents, and delivers synthetically versatile five-membered carbocycles containing an all-carbon quaternary stereogenic center remote from the reaction site in excellent enantioselectivity.

Item Type:	Journal Article
Publication:	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Publisher:	AMER CHEMICAL SOC
Additional Information:	Copyright for this article belongs to the AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	19 Mar 2015 12:08
Last Modified:	19 Mar 2015 12:08
URI:	http://eprints.iisc.ac.in/id/eprint/51049

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