ePrints@IIScePrints@IISc Home | About | Browse | Latest Additions | Advanced Search | Contact | Help

Synthesis, molecular docking and anti-mycobacterial evaluation of new imidazo1,2-a]pyridine-2-carboxamide derivatives

Jose, Gilish and Kumara, Suresha TH and Nagendrappa, Gopalpur and Sowmya, HBV. and Sriram, Dharmarajan and Yogeeswari, Perumal and Sridevi, Jonnalagadda Padma and Row, Tayur Guru N and Hosamani, Amar A and Ganapathy, Sujan PS and Chandrika, N and Narendra, LV (2015) Synthesis, molecular docking and anti-mycobacterial evaluation of new imidazo1,2-a]pyridine-2-carboxamide derivatives. In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 89 . pp. 616-627.

[img] PDF
eur_jou_med_chem_89_616_2015.pdf - Published Version
Restricted to Registered users only

Download (1MB) | Request a copy
Official URL: http://dx.doi.org/ 10.1016/j.ejmech.2014.10.079

Abstract

New anti-tubercular agents, imidazo1,2-a]pyridine-2-carboxamide derivatives (5a-q) have been designed and synthesized. The structural considerations of the designed molecules were further supported by the docking study with a long-chain enoyl-acyl carrier protein reductase (InhA). The chemical structures of the new compounds were characterized by IR, H-1 NMR, C-13 NMR, HRMS and elemental analysis. In addition, single crystal X-ray diffraction has also been recorded for compound 5f. Compounds were evaluated in vitro against Mycobacterium tuberculosis H37Rv, and cytotoxicity against HEK-293T cell line. Amongst the tested compounds 5j, 5l and 5q were emerged as good anti-tubercular agents with low cytotoxicity. The structure-anti TB activity relationship of these derivatives was explained by molecular docking. (C) 2014 Elsevier Masson SAS. All rights reserved.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 23 RUE LINOIS, 75724 PARIS, FRANCE
Keywords: Anti-mycobacterial activity; Imidazopyridine amide; InhA; Tuberculosis; X-ray crystallography
Department/Centre: Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Depositing User: Id for Latest eprints
Date Deposited: 04 Mar 2015 12:08
Last Modified: 04 Mar 2015 12:08
URI: http://eprints.iisc.ac.in/id/eprint/50950

Actions (login required)

View Item View Item