Synthesis, antioxidant, and cytotoxic activities of bis(oxazolyl/thiazolyl/imidazolyl)amidomethanesulfonyl Acetamides

Reddy, Putta Ramachandra and Seenaiah, Dandu and Padmaja, Adivireddy and Padmavathi, Venkatapuram and Krishna, Narra Siva (2015) Synthesis, antioxidant, and cytotoxic activities of bis(oxazolyl/thiazolyl/imidazolyl)amidomethanesulfonyl Acetamides. In: MEDICINAL CHEMISTRY RESEARCH, 24 (1). pp. 86-98.

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Abstract

A new class of bis(oxazolyl/thiazolyl/imidazolyl)amidomethanesulfonyl acetamides was prepared from the respective (oxazolyl/thiazolyl/imidazolyl)carbamoyl-methylthio acetic acid and studied their antioxidant activity and cytotoxic activitity against A549 lung adenocarcinoma cells. The methyl-substituted sulfonyl bisoxazoles exhibited excellent radical scavenging activity. On the other hand, the chloro-substituted sulfonyl bisthiazoles (IC50 = 49 A mu M) and sulfonyl bisimidazoles (IC50 = 24 A mu M) showed noticeable cytotoxic activity on A549 cells.

Item Type:	Journal Article
Publication:	MEDICINAL CHEMISTRY RESEARCH
Publisher:	SPRINGER BIRKHAUSER
Additional Information:	Copyright for this article belongs to the SPRINGER BIRKHAUSER, 233 SPRING STREET, 6TH FLOOR, NEW YORK, NY 10013 USA
Keywords:	Oxazole; Thiazole; Imidazole; Antioxidant activity; Cytotoxic activity
Department/Centre:	Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited:	14 Feb 2015 13:34
Last Modified:	14 Feb 2015 13:34
URI:	http://eprints.iisc.ac.in/id/eprint/50812

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