Novel M-Superfamily and T-Superfamily conotoxins and contryphans from the vermivorous snail Conus figulinus

Rajesh, Rajaian Pushpabai (2015) Novel M-Superfamily and T-Superfamily conotoxins and contryphans from the vermivorous snail Conus figulinus. In: JOURNAL OF PEPTIDE SCIENCE, 21 (1). pp. 29-39.

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Abstract

The venom of Conus figulinus, a vermivorous cone snail, found in the south east coast of India, has been studied in an effort to identify novel peptide toxins. The amino acid sequences of seven peptides have been established using de novo mass spectrometric based sequencing methods. Among these, three peptides belong to the M-Superfamily conotoxins, namely, Fi3a, Fi3b, and Fi3c, and one that belongs to the T-Superfamily, namely, Fi5a. The other three peptides are contryphans, namely, contryphans fib, fic, and fid. Of these Fi3b, Fi3c, Fi5a, and contryphan fib are novel and are reported for the first time from venom of C.figulinus. The details of the sequencing methods and the relationship of these peptides with other M'-Superfamily conotoxins from the fish hunting and mollusk hunting clades are discussed. These novel peptides could serve as a lead compounds for the development of neuropharmacologically important drugs. Copyright (c) 2014 European Peptide Society and John Wiley & Sons, Ltd.

Item Type:	Journal Article
Publication:	JOURNAL OF PEPTIDE SCIENCE
Publisher:	WILEY-BLACKWELL
Additional Information:	Copyright for this article belongs to the WILEY-BLACKWELL, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
Keywords:	cone snails; de novosequencing; disulfide rich peptides; venom; M-Superfamily conotoxins; T-Superfamily Conotoxins; contryphans
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	28 Jan 2015 04:21
Last Modified:	28 Jan 2015 04:21
URI:	http://eprints.iisc.ac.in/id/eprint/50745

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