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A quinazoline derivative as quick-response red-shifted reporter for nanomolar Al3+ and applicable to living cell staining

Mukherjee, Manjira and Sen, Buddhadeb and Pal, Siddhartha and Banerjee, Samya and Lohar, Somenath and Chattopadhyay, Pabitra (2014) A quinazoline derivative as quick-response red-shifted reporter for nanomolar Al3+ and applicable to living cell staining. In: RSC ADVANCES, 4 (109). pp. 64014-64020.

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Official URL: http://dx.doi.org/ 10.1039/c4ra10836a

Abstract

A newly synthesized and structurally characterized quinazoline derivative (L) has been shown to act as a quick-response chemosensor for Al3+ with a high selectivity over other metal ions in water-DMSO. In the presence of Al3+, L shows a red-shifted ratiometric enhancement in fluorescence as a result of internal charge transfer and chelation-enhanced fluorescence through the inhibition of a photo-induced electron transfer mechanism. This probe detects Al3+ at concentrations as low as 1.48 nM in 100 mM HEPES buffer (DMSO-water, 1 : 9 v/v) at biological pH with a very short response time (15-20 s). L was applied to biological imaging to validate its utility as a fluorescent probe for monitoring Al3+ ions in living cells, illustrating its value in practical environmental and biological systems.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
Department/Centre: Division of Chemical Sciences > Inorganic & Physical Chemistry
Depositing User: Id for Latest eprints
Date Deposited: 13 Jan 2015 05:05
Last Modified: 13 Jan 2015 05:05
URI: http://eprints.iisc.ac.in/id/eprint/50652

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