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Selective Review of Proton Magnetic Resonance Spectroscopy in Schizophrenia

Rao, Naren P (2014) Selective Review of Proton Magnetic Resonance Spectroscopy in Schizophrenia. In: JOURNAL OF THE INDIAN INSTITUTE OF SCIENCE, 94 (4). pp. 465-471.

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Abstract

Magnetic Resonance Spectroscopy (MRS) offers a unique opportunity to measure brain metabolites in-vivo, and in doing so enables one to understand the brain function and cellular processes implicated in the pathophysiology of psychiatric disorders. MRS, in addition to being non-invasive, is devoid of radioactive tracers and ionizing radiation, a distinct advantage over other imaging modalities like positron emission tomography and single photon emission computed tomography. With advances in MRS technique it is now possible to quantify concentrations of relevant compounds like neurotransmitters, neuronal viability markers and pharmacological compounds. Majority of the MRS studies have examined the neurometabolites in schizophrenia, a common and debilitating psychiatric disorder. Abnormalities in N Acetyl aspartate and Glutamate are consistently reported while the reports regarding the myoinsoitol and choline are inconsistent. These abnormalities are not changed across the illness stages and despite treatment. However, multiple technical challenges have limited the widespread use of MRS in psychiatric disorders. Guidelines for uniform acquisition and preprocessing are need of the hour, which. would increase the replicability and validity of MRS measures in psychiatry. Finally long term, prospective, longitudinal studies are required in different psychiatric disorders for potential clinical applications.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the INDIAN INST SCIENCE, INDIAN INST SCIENCE, BANGALORE 560012, INDIA
Department/Centre: Division of Biological Sciences > Centre for Neuroscience
Depositing User: Id for Latest eprints
Date Deposited: 13 Jan 2015 04:58
Last Modified: 13 Jan 2015 04:58
URI: http://eprints.iisc.ac.in/id/eprint/50649

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