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Studying Microstructure in Molecular Crystals With Nanoindentation: Intergrowth Polymorphism in Felodipine

Mishra, Manish Kumar and Desiraju, Gautam R and Ramamurty, Upadrasta and Bond, Andrew D (2014) Studying Microstructure in Molecular Crystals With Nanoindentation: Intergrowth Polymorphism in Felodipine. In: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 53 (48). pp. 13102-13105.

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Official URL: http://dx.doi.org/ 10.1002/anie.201406898

Abstract

Intergrowth polymorphism refers to the existence of distinct structural domains within a single crystal of a compound. The phenomenon is exhibited by form II of the active pharmaceutical ingredient felodipine, and the associated microstructure is a significant feature of the compound's structural identity. Employing the technique of nanoindentation on form II reveals a bimodal mechanical response on specific single-crystal faces, demonstrating distinct properties for two polymorphic forms within the same crystal.

Item Type: Journal Article
Additional Information: Copyright for this article belongs to the WILEY-V C H VERLAG GMBH, BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY
Keywords: crystal engineering; microstructure; nanoindentation; polymorphism; X-ray diffraction
Department/Centre: Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Depositing User: Id for Latest eprints
Date Deposited: 12 Jan 2015 05:10
Last Modified: 12 Jan 2015 05:10
URI: http://eprints.iisc.ac.in/id/eprint/50571

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