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Enantiospecific Formal Total Synthesis of Iriomoteolide 3a

Kumar, Mothish S and Prasad, Kavirayani R (2014) Enantiospecific Formal Total Synthesis of Iriomoteolide 3a. In: CHEMISTRY-AN ASIAN JOURNAL, 9 (12). pp. 3431-3439.

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Official URL: http://dx.doi.org/ 10.1002/asia.201402593

Abstract

A formal total synthesis of the marine macrolide iriomoteolide3a is described. Salient features of the synthesis include the elaboration of a -keto phosphonate derived from D-(-)-tartaric acid and the extension of a chiral butyrolactone derived from L-glutamic acid. Ring-closing metathesis is employed to construct the macrolactone core of the natural product.

Item Type: Journal Article
Additional Information: Copyright for this article belongs to the WILEY-V C H VERLAG GMBH, BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY
Keywords: iriomoteolide3a; lactones; macrocycles; natural products; total synthesis
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Depositing User: Id for Latest eprints
Date Deposited: 12 Jan 2015 04:54
Last Modified: 12 Jan 2015 04:54
URI: http://eprints.iisc.ac.in/id/eprint/50561

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