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SIRT6 Promotes COX-2 Expression and Acts as an Oncogene in Skin Cancer

Ming, Mei and Han, Weinong and Zhao, Baozhong and Sundaresan, Nagalingam R and Deng, Chu-Xia and Gupta, Mahesh P and He, Yu-Ying (2014) SIRT6 Promotes COX-2 Expression and Acts as an Oncogene in Skin Cancer. In: CANCER RESEARCH, 74 (20). pp. 5925-5933.

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Official URL: http://dx.doi.org/ 10.1158/0008-5472.CAN-14-1308

Abstract

SIRT6 is a SIR2 family member that regulates multiple molecular pathways involved in metabolism, genomic stability, and aging. It has been proposed previously that SIRT6 is a tumor suppressor in cancer. Here, we challenge this concept by presenting evidence that skin-specific deletion of SIRT6 in the mouse inhibits skin tumorigenesis. SIRT6 promoted expression of COX-2 by repressing AMPK signaling, thereby increasing cell proliferation and survival in the skin epidermis. SIRT6 expression in skin keratinocytes was increased by exposure to UVB light through activation of the AKT pathway. Clinically, we found that SIRT6 was upregulated in human skin squamous cell carcinoma. Taken together, our results provide evidence that SIRT6 functions as an oncogene in the epidermis and suggest greater complexity to its role in epithelial carcinogenesis. (C) 2014 AACR.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the AMER ASSOC CANCER RESEARCH, 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Depositing User: Id for Latest eprints
Date Deposited: 04 Dec 2014 04:48
Last Modified: 04 Dec 2014 04:48
URI: http://eprints.iisc.ac.in/id/eprint/50364

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