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Iron(III) Catecholates for Cellular Imaging and Photocytotoxicity in Red Light

Basu, Uttara and Pant, Ila and Khan, Imran and Hussain, Akhtar and Kondaiah, Paturu and Chakravarty, Akhil R (2014) Iron(III) Catecholates for Cellular Imaging and Photocytotoxicity in Red Light. In: CHEMISTRY-AN ASIAN JOURNAL, 9 (9). pp. 2494-2504.

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Official URL: http://dx.doi.org/10.1002/asia.201402207

Abstract

Iron(III) complexes Fe(L)(L') (NO3)]-in which L is phenyl-N, N-bis(pyridin-2-yl) methyl]methanamine (1), (anthracen-9-yl)N, N-bis(pyridin-2-yl) methyl] methanamine (2), (pyreny-1-yl)-N, N-bis(pyridin- 2-yl) methyl] methanamine (3-5), and L' is catecholate (1-3), 4-tert-butyl catecholate (4), and 4-(2-aminoethyl)benzene- 1,2-diolate (5)-were synthesized and their photocytotoxic proper-ties examined. The five electron-paramagnetic complexes displayed a FeIII/ Fe-II redox couple near similar to 0.4 V versus a saturated calomel electrode (SCE) in DMF/0.1m tetrabutylammonium perchlorate (TBAP). They showed unpre-cedented photocytotoxicity in red light (600-720 nm) to give IC50-15 mm in various cell lines by means of apoptosis to generate reactive oxygen species. They were ingested in the nucleus of HeLa and HaCaT cells in 4 h, thereby interacting favorably with calf thymus (ct)-DNA and photocleaving pUC19 DNA in red light of 785 nm to form hydroxyl radicals.

Item Type: Journal Article
Additional Information: Copyright for this article belongs to the WILEY-V C H VERLAG GMBH, BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY.
Keywords: apoptosis; bioinorganic chemistry; DNA cleavage; iron; photocytotoxicity
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Division of Chemical Sciences > Inorganic & Physical Chemistry
Depositing User: Id for Latest eprints
Date Deposited: 08 Nov 2014 05:30
Last Modified: 15 Nov 2014 17:50
URI: http://eprints.iisc.ac.in/id/eprint/50203

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