A new microscopic insight into membrane penetration and reorganization by PETIM dendrimers

Bhattacharya, R and Kanchi, Subbarao and Roobala, C and Lakshminarayanan, A and Seeck, Oliver H and Maiti, Prabal K and Ayappa, KG and Jayaraman, N and Basu, JK (2014) A new microscopic insight into membrane penetration and reorganization by PETIM dendrimers. In: SOFT MATTER, 10 (38). pp. 7577-7587.

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Abstract

Dendrimers are highly branched polymeric nanoparticles whose structure and topology, largely, have determined their efficacy in a wide range of studies performed so far. An area of immense interest is their potential as drug and gene delivery vectors. Realizing this potential, depending on the nature of cell surface-dendrimer interactions, here we report controlled model membrane penetration and reorganization, using a model supported lipid bilayer and poly(ether imine) (PETIM) dendrimers of two generations. By systematically varying the areal density of the lipid bilayers, we provide a microscopic insight, through a combination of high resolution scattering, atomic force microscopy and atomistic molecular dynamics simulations, into the mechanism of PETIM dendrimer membrane penetration, pore formation and membrane re-organization induced by such interactions. Our work represents the first systematic observation of a regular barrel-like membrane spanning pore formation by dendrimers, tunable through lipid bilayer packing, without membrane disruption.

Item Type:	Journal Article
Publication:	SOFT MATTER
Publisher:	ROYAL SOC CHEMISTRY
Additional Information:	Copy right for this article belongs to the ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND.
Department/Centre:	Division of Chemical Sciences > Organic Chemistry Division of Mechanical Sciences > Chemical Engineering Division of Physical & Mathematical Sciences > Physics
Date Deposited:	08 Nov 2014 05:17
Last Modified:	08 Nov 2014 05:17
URI:	http://eprints.iisc.ac.in/id/eprint/50182

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