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Comprehending the Formation of Eutectics and Cocrystals in Terms of Design and Their Structural Interrelationships

Cherukuvada, Suryanarayan and Row, Tayur Guru N (2014) Comprehending the Formation of Eutectics and Cocrystals in Terms of Design and Their Structural Interrelationships. In: CRYSTAL GROWTH & DESIGN, 14 (8). pp. 4187-4198.

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Official URL: http://dx.doi.org/ 10.1021/cg500790q

Abstract

The phenomenon of cocrystallization, which encompasses the art of making multicomponent organic solids such as cocrystals, solid solutions, eutectics, etc. for novel applications, has been less studied in terms of reliably and specifically obtaining a desired cocrystallization product and the issues that govern their formation. Further, the design, structural, and functional aspects of organic eutectics have been relatively unexplored as compared to solid solutions and cocrystals well-established by crystal engineering principles. Recently, eutectics were proposed to be designable materials on par with cocrystals, and herein we have devised a systematic approach, based on the same crystal engineering principles, to specifically and desirably make both eutectics and cocrystals for a given system. The propensity for strong homomolecular synthons over weak heteromolecular synthons and vice versa during supramolecular growth was successfully utilized to selectively obtain eutectics and cocrystals, respectively, in two model systems and in two drug systems. A molecular level understanding of the formation of eutectics and cocrystals and their structural interrelationships which is significant from both fundamental and application viewpoints is discussed. On the other hand, the obscurity in establishing a low melting combination as a eutectic or a cocrystal is resolved through phase diagrams.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
Department/Centre: Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Depositing User: Id for Latest eprints
Date Deposited: 04 Sep 2014 11:04
Last Modified: 04 Sep 2014 11:04
URI: http://eprints.iisc.ac.in/id/eprint/49762

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