Toward the total synthesis of a lagunamide B analogue

Pal, Sudip and Chakraborty, Tushar Kanti (2014) Toward the total synthesis of a lagunamide B analogue. In: TETRAHEDRON LETTERS, 55 (24). pp. 3469-3472.

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Abstract

Lagunamides, isolated from a marine cyanobacterium Lyngbya majuscule found in Singapore, showed very potent activities against Plasmodium falciparum and murine leukemia cell line (P388). Herein, a concise synthetic approach toward the total synthesis of a lagunamide B analogue is discussed. Macrolactonization, HWE-olefination, and modified Crimmin's aldol are some of the key reactions featured in this synthesis. (C) 2014 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Publication:	TETRAHEDRON LETTERS
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Additional Information:	Copyright for this article belongs to the PERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
Keywords:	Macrolactonization; Macrolactamization; Horner-Wadsworth-Emmons olefination; Crimmin's aldol; 2-Methyl-6-nitrobenzoic anhydride (MNBA)
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	14 Aug 2014 10:06
Last Modified:	14 Aug 2014 10:06
URI:	http://eprints.iisc.ac.in/id/eprint/49553

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