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Hot pressed silver doped hydroxyapatite biomaterials with bactericidal properties against magnetotactic bacteria

Mandal, S and Sunilkumar, B and Kumar, A and Basu, B (2014) Hot pressed silver doped hydroxyapatite biomaterials with bactericidal properties against magnetotactic bacteria. In: MATERIALS TECHNOLOGY, 29 (B1, SI). B21-B25.

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Official URL: http://dx.doi.org/10.1179/1753555713Y.0000000089

Abstract

Hydroxyapatite (HA) is widely being researched for hard tissue replacement for its good osseointegration and biocompatibility property. However, the inferior antibacterial property of HA often results in infection at host site, and this leads to rejection of the implant. The antibacterial property of silver (Ag) is well known and in the past decade or so, the application of Ag is reinvented in medicinal applications like catheters, vascular grafts and orthopaedic implants. In this respect, the present work reports the synthesis of Ag doped HA using hot pressing in argon atmosphere. This work also reports the effect of HA-Ag composition on bacterial colonisation during in vitro study. The bactericidal property of Ag doped HA has been investigated against magnetotactic bacteria, a `magnetite' containing bacteria. Magnetotactic bacteria were seeded onto pellets, and the adhesion of bacteria was evaluated using scanning electron microscopy. It was confirmed that incorporation of Ag in HA leads to improved bactericidal property.

Item Type: Journal Article
Additional Information: Copyright for this article belongs to the MANEY PUBLISHING England
Keywords: HA; Ag; HA-xAg; Magnetotactic bacteria; Bactericidal
Department/Centre: Division of Chemical Sciences > Materials Research Centre
Depositing User: Id for Latest eprints
Date Deposited: 16 Jul 2014 09:21
Last Modified: 16 Jul 2014 09:21
URI: http://eprints.iisc.ac.in/id/eprint/49463

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