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Inflammation and cancer stem cells

Shigdar, Sarah and Li, Yong and Bhattacharya, Santanu and O'Connor, Michael and Pu, Chunwen and Lin, Jia and Wang, Tao and Xiang, Dongxi and Kong, Lingxue and Wei, Ming Q and Zhu, Yimin and Zhou, Shufeng and Duan, Wei (2014) Inflammation and cancer stem cells. In: CANCER LETTERS, 345 (2, SI). pp. 271-278.

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Official URL: http://dx.doi.org/10.1016/j.canlet.2013.07.031

Abstract

Cancer stem cells are becoming recognised as being responsible for metastasis and treatment resistance. The complex cellular and molecular network that regulates cancer stem cells and the role that inflammation plays in cancer progression are slowly being elucidated. Cytokines, secreted by tumour associated immune cells, activate the necessary pathways required by cancer stem cells to facilitate cancer stem cells progressing through the epithelial-mesenchymal transition and migrating to distant sites. Once in situ, these cancer stem cells can secrete their own attractants, thus providing an environment whereby these cells can continue to propagate the tumour in a secondary niche. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

Item Type: Journal Article
Additional Information: Copyright for this article belongs to the ELSEVIER IRELAND LTD, ELSEVIER HOUSE, IRELAND
Keywords: Cancer stem cells; Inflammation; Microenvironment; Epithelial-mesenchymal transition; Epigenetics
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Depositing User: Id for Latest eprints
Date Deposited: 27 May 2014 07:48
Last Modified: 27 May 2014 07:48
URI: http://eprints.iisc.ac.in/id/eprint/49014

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