Reddy, Putta Ramachandra and Reddy, Guda Mallikarjuna and Padmaja, Adivireddy and Padmavathi, Venkatapuram and Kondaiah, Paturu and Krishna, Narra Siva (2014) Synthesis, Antioxidant, and Cytotoxic Activities of N-Azole Substituted Thiomorpholine Derivatives. In: ARCHIV DER PHARMAZIE, 347 (3). pp. 221-228.
Full text not available from this repository. (Request a copy)Abstract
A new class of N-azole substituted thiomorpholine derivatives were prepared and their antioxidant and cytotoxic activities were studied. The methyl substituted oxazolyl thiomorpholine dioxide 9b exhibited radical scavenging activity greater than the standard ascorbic acid. On the other hand, the thiazolyl thiomorpholine 10c having a chloro substituent on the aromatic ring was identified as a remarkable lead molecule for cytotoxic activity against A549 and HeLa cells, with IC50 values of 10.1 and 30.0 mu M, respectively.
| Item Type: | Journal Article |
|---|---|
| Publication: | ARCHIV DER PHARMAZIE |
| Publisher: | WILEY-V C H VERLAG GMBH |
| Additional Information: | Copyright for this article belongs to the WILEY-V C H VERLAG GMBH, BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY |
| Keywords: | Antioxidant activity; Cytotoxicity; Imidazoles; Oxazoles; Thiazoles; Thiomorpholines |
| Department/Centre: | Division of Biological Sciences > Molecular Reproduction, Development & Genetics |
| Date Deposited: | 11 Apr 2014 09:50 |
| Last Modified: | 11 Apr 2014 09:52 |
| URI: | http://eprints.iisc.ac.in/id/eprint/48830 |
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